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STRYCHNOS TINCTURE
(tinctura Strychnos guianensis)

from AMAZON HERBS®




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Overview

STRYCHNOS GUIANENSIS Strychnos guianensis (Curare) is a climbing woody vine (liana) growing in the Amazon rainforest.
The curare (the main poison) is obtained from the bark of this liana. It works by affecting neuromuscular transmissions. It is basically a natural muscle relaxant; causes death by paralyzing the respiratory system of primates, resulting in asphyxiation.
Used by the Amerindians as an arrow poison together with other plants that speed up the heartbeat. The animal, shot with an arrow, of which the point is dipped in the poison, remains alert throughout the whole process.
However, the bark is also a potent natural sedative and can be used in the treatment of convulsive and spasmodic disorders, when applied by a trained herbalist or homeopath.


Constituents

Alkaloid D-tubocurarine, mono- and bisindole quaternary alkaloids: Guiaflavine, 5',6'-dehydroguiaflavine, 9-methoxy-Nb-methylgeissoschizol; C-alkaloid O, fluorocurine, mavacurine, macusine B and C-profluorocurine.


Pharmacology

Mono- and bisindole quaternary alkaloids isolated from the stem bark of Strychnos guianensis have been shown to be effective blockers of neuromuscular transmission in mice. A human clonal cell line (TE671) expressing muscle-type nicotinic acetylcholine receptors. The agonist carbamylcholine activated a receptor-mediated 86Rb+ efflux and this activation was antagonized by the indole alkaloids, the most active being bisindole bisquaternary compounds. The most effective antagonist, guiachrysine, had an IC50 around 0.43 µM in the presence of 0.5 mM carbamylcholine, compared to 0.16 µM for d-tubocurarine, the most potent curarizing alkaloid. Guiaflavine and 5',6'-dehydroguiaflavine were slightly less effective. Monoindole compounds were 10 to 100 times less potent than bisindole alkaloids.


Dosage

Tincture: check with your herbalist or homeopath

Warning

May be extremely poisonous!

STRYCHNOS GUIANENSIS BARK Reference

Foldes, F.F. "Anesthesia before and after curare", Anasthesieabteilung des Albert-Einstein-College of Medicine.
Anaesthesiol Reanim, 1993, 18(5):128-31. (retrieved June 20 2005) James, Mel. "Harold Griffith",Heirloom Series, Volume 6. (retrieved June 20 2005)
"Curare", Blue Planet Biomes, 2000. (retrieved September 27 2005)
Bisindole alkaloids from Strychnos guianensis are effective antagonists of nicotinic acetylcholine receptors in cultured human TE671 cells.
Wins P, Margineanu I, Penelle J, Angenot L, Grisar T, Bettendorff L.

Center for Cellular and Molecular Neurobiology, University of Liege, place Delcour, 17, 4020 Liege, Belgium
Quaternary indole alkaloids from the stem bark of Strychnos guianensis.
Penelle J, Tits M, Christen P, Molgo J, Brandt V, Frederich M, Angenot L.

Universite de Liege, Institut de Pharmacie, CHU, Belgium. jacques.penelle@ulg.ac.be




The above presentation is for informational and educational purposes only.
It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage.
For many of the conditions discussed, treatment with prescription or over - the - counter (OTC) medication is also available.
Consult your doctor, practitioner, and/or pharmacist for any health problem and before using dietary supplements or before making any changes in prescribed medications.


Buy 6 bottles save 10%; buy 12 bottles and save 15%!

Item Description Unit Price Quantity

Strychnos guianensis tincture 1 fl. oz (29.6 cc) US$55.00
Strychnos guianensis tincture 6 x 1 fl. oz US$297.00
Strychnos guianensis tincture 12 x 1 fl. oz US$561.00
Strychnos guianensis tincture 2 fl. oz (59.1 cc) US$100.00
Strychnos guianensis tincture 6 x 2 fl. oz US$540.00
Strychnos guianensis tincture 12 x 2 fl. oz US$1020.00


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