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| GOSSYPIUM TINCTURE (tinctura Gossypium barbadense) from AMAZON HERBS® |
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OVERVIEW)
This brushy tropical plant has hypotensive (blood pressure lowering) effect and antifungal
properties.It is also one of the safest and most certain herbal abortifacients (substance that causes pregnancy to end prematurely and causes an abortion). Other uses are: as an emmenagogue (menstruation stimulant), a substitute for ergot (fungus that procedure certain alkaloids used in medicine) and to check hemorrhage (bleeding). Flower buds are used by the Amerindians for earache. The leaves are used against parasites and to eliminate filariasis* (filaria). Other traditional medicinal applications include the seeds that are used in dysentery. The seed oil is used to clear freckles and spots from the skin. PHYTOCHEMICALS Root bark contains ca 3% of a reddish acidic resin, a volatile oil, a phenolic acid (probably 2,3-dihydrobenzoic acid; salicylic acid, a colorless phenol, betaine, a fatty alcohol, a phytosterol (C27H46O), a hydrocarbon (probably triacontane), ceryl alcohol and oleic and palmitic acid. Hager's Handbook (List and Horhammer, 1969–1979) also lists isoquercitrin, quercimeritrin, quercetin-3'-glucoside, hirsutrin, isoastragalin, palmitic acid, oleic acid, linoleic acid, -pinene, -caryophyllene, bisabolol, caryophyllenepoxide, bisabolenoxide, abscissin II, serotonin, chrysanthemin, gossypicyanin and histamine. Gossypol (polyphenol). PHARMACOLOGY )
The blood-pressure-lowering effect of the decoction of G. barbadense leaves
collected from Suriname was evaluated.Although it is still not known which compound(s) is (are) the active substance(s), the results obtained may explain the use of this plant in Traditional Medicine of Suriname and other South American countries. Natural gossypol (GP) is made up of two mirror image molecules. (+)GP (plus gossypol) and (-)GP (minus gossypol). There is ongoing research to use Gossypol as a natural alternative to vasectomy (permanent method of birth control). Gossypol has also long been known to possess anti-malarial properties. The root, bark and the pigmented glands of the seeds contain gossypol, it is shown to be antiviral; the influenza virus is inactivated by it. Gossypol is also effective against herpes and seems to increase interferon levels naturally. Interferons are proteins and part of the natural defense of the body. Women use it against uterus disorders such as uterine bleeding, uterine myoma and endometriosis (painful disorder, tissue that lines the inside of the uterus grows outside of it). Gossypol (actually a yellow pigment) extracted from the root and seed), has demonstrated in vitro effects on cell cycle regulation and anti-tumor activity against mammary carcinoma cell lines. The cell cycle regulatory effects of gossypol suggest a potential role for gossypol as a modulating agent in conjunction with other cell cycle specific compounds. According to Chinese studies, gossypol is effective as a non-hormonal male contraceptive; however, it has been found to have irreversible effects on male fertility. It is now being studied for clinical applications in cancer therapies. It has been tested for use against prostate and other cancers. A study of the effect of gossypol on the growth of human androgen-independent prostate cancer cell line (PC3) showed gossypol to be a potent inhibitor of prostate cancer cell growth. Gossypol has demonstrated in vitro effects on cell cycle regulation and anti-tumor activity against mammary carcinoma cell lines. The natural form of gossypol has been extensively tested in humans and is well tolerated for long-term use. Using the more active form, (-)GP for example, in combination with radiation or chemotherapy, it may soon find its new role in the fight against cancer. DOSAGE Tincture: 1 - 3 ml daily. Infusion (herbal tea): 1 - 3 cups daily. SIDE EFFECTS It may have abortifacient effects; when pregnant and/or lactating. Adverse reactions; the irreversible effects of gossypol on male fertility have been documented. It can cause hypokalemia (low potassium level) in some people. *Lymphatic Filariasis is a parasitic and infectious tropical disease, caused by three thread-like parasitic filarial worms called nematode worms and transmitted by mosquitoes. REFERENCE Medicinal plants in Suriname: hypotensive effect of Gossypium barbadense. Hasrat JA, Pieters L, Vlietinck AJ. Department of Pharmacology, Faculty of Medicinal Sciences, Paramaribo, Suriname. Occurrence of (+)- and (-)-gossypol in wild species of cotton and in Gossypium hirsutum Var. marie-galante (Watt) Hutchinson. Stipanovic RD, Puckhaber LS, Bell AA, Percival AE, Jacobs J. Southern Plains Agricultural Research Center, Agricultural Research Service, U.S. Department of Agriculture, 2765 F&B Road, College Station, Texas 77845, USA. rdstip@cpru.usda.gov Isolation of (-)-gossypol from natural plant. Zhou RH, Lin XD National Research Institute for Family Planning, Beijing, China. Medicinal plants in Suriname: hypotensive effect of Gossypium barbadense. Pieters, L., Vlietinck, A. J., Hasrat, J. A. Journal of Pharmacy and Pharmacology, 2004 (Vol. 56) (No. 3) 381-387. Department of Pharmacology, Faculty of Medicinal Sciences, Paramaribo, Suriname. Oral Gossypol in the Treatment of Patients with Refractory Metastatic Breast Cancer: A Phase I/II Clinical Trial. Catherine Van Poznak, Andrew D. Seidman, Marcus M. Reidenberg, Mark M. Moasser, Nancy Sklarin,Kimberly Van Zee, Patrick Borgen, Marc Gollub, Doreen Bacotti and T-J Yao. Inhibition of human prostate cancer cells growth by gossypol is associated with stimulation of transforming growth factor-beta. Shidaifat F, et al. Cancer Lett. 1996 Oct 1;107(1):37-44. The above presentation is for informational and educational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage. For many of the conditions discussed, treatment with prescribed (RX) or over - the - counter (OTC) medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using dietary supplements or before making any changes in prescribed medications. |
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