CURCUMIN TINCTURE - TURMERIC EXTRACT TROPILAB.

CURCUMIN TINCTURE
(tinctura CURCUMA XANTHORRHIZA)
(tinctura CURCUMA LONGA)

from AMAZON HERBS®

Overview

Traditionally, the rhizomes (underground root) of Curcuma longa and Xanthorriza (Turmeric spices), from the Zingeberaceae family, have been successfully used as a natural remedy for liver problems and indigestion.
These yellow spices are used widely in the Indian- and Caribbean cuisine.
Whole turmeric is more adequate than isolated curcumin for inflammatory disorders, including arthritis, tendonitis, and autoimmune conditions.
Turmeric has been used for thousands of years in Ayurvedic and Traditional Chinese Medicine to manage many diseases and ailments.
It stimulate digestion, boosts liver function, against gout and regulates menstruation.
The spices have also been used successfully against internal parasites. Controlling the herpes virus (makes cells more resistant to invasion by this virus). Its strong anti-inflammatory action will also help control discomfort caused by outbreaks.
Many clinical trials in humans are underway, studying the effect of this spice in diseases, including multiple myeloma, viruses, pancreatic cancer, myelodysplastic syndromes, colon cancer, psoriasis, leishmaniasis and Alzheimer's disease.
It also may be used to avoid bone loss, use as an effective blood thinner and against osteoporosis.

For more information about the handling of gout with Curcumin, go to the GOUT PAGE.

Constituents

Curcuminoids* (curcumin, dicinnamoyl - methane,bis - demethoxy - curcumin, demethoxy curcumin). Terpenoids (sesgueterpenoids, monoterpenoid), Xanthorrhizol (sesquiterpenoid). Essential oils (camphor, isofurano - germacrese, cineo, borneol). Major volatile components: 1,8-cineol and curzerenone. Cinnamaldehyde. Starch / carbohydrate (30% - 40%). Curcuma xanthorriza contain 6 - 11 % of 1 - cyclo iso prene myrcene essential oil.

*Curcuminoids (Curcumin and the related compounds) are natural polyphenols.

Pharmacology

About 2 - 8 percent of turmeric is made up of curcuminoids.
Curcumin has been proven to exhibit anticarcinogenic, anti-inflammatory and powerful antioxidant properties (ability to neutralize free radicals). It also stimulates the immune functions of macrophages (type of white blood cell of the immune system).
These antioxidant properties are far stronger than those of vitamin E and C. They are strong enough to scavenge the hydroxyl radical (the most reactive of all oxidants).
Curcumin main application is as an anti-inflammatory herbal drug that produces far fewer side effects than commonly used prescription drugs.
This inflammation includes those caused by (rheumatoid) arthritis, swelling pain, muscle sprain, surgical incisions.
It is an adequate painkiller, comparable to Ibuprofen but without the side effects associated with this OTC drug.
In addition, it lowers LDL cholesterol and is able to cure hepatitis (it is a broad spectrum hepatoprotective agent).
Other constituents, such as xanthorrhizol also have excellent antimicrobial activity, against oral microorganisms.

Curcumin Forte
(Curcuma longa) has almost twice as much Curcuminoids, the most active ingredient in the extract.

Curcumin and Alzheimer's Disease
Curcumin blocks the Tumor Necrosis Factor (TNF); in addition it crosses the blood-brain-barrier which can make it extremely useful in combating brain cancer medicine.

When used for the cancer fighting capabilities, it shows a remarkable effect in intervening with initiation and growth of cancer cells and tumors.
It inhibits the progression of chemically induced colon and skin cancers.
Curcumin has been shown to enhance the effectiveness of certain, anti cancer drugs and also improve the effectiveness of radiation remedy.
The tumor cells are avoided from developing the so called radiation resistance.
Curcumin can both avoid - and handle many cancers. It suppresses LOX 2, NOS MMP 9 and COX (these are enzymes that make carcinogens much more active once they are in the body; they also allow cancerous cells to grow new blood vessels). The area of the kinase inhibitors is a hot area of oncology drug development. There are many of these protein kinases and they act as message lines into the DNA command center of the cells. Curcumin can adequate block a number of these lines. It has the ability to naturally avoid skin cancer. Is adequate against colon cancer. It also enhances immunity and stops angiogenesis (ability to enable tumors to create an own blood supply).

Xanthorrhizol (sesquiterpenoid compound isolated from the rhizome), exerts anti-metastatic activity in vivo.
A recent study suggests that combination of curcuminoids, essential oils of C. domestica and C. xanthorrhizza, have anti-inflammatory effects comparable to Piroxicam (Feldene®), a known anti-inflammatory agent.
In laboratory tests, Curcumin + the cancer drug Taxol® (Paclitaxel) performed far better in controlling lung cancer than when given Taxol® alone.
Curcumin potentiates Cisplatin (a chemotherapy medication) in head and neck cancers.
A primary reason that head and neck cancer remedies fail is that the tumor cells become resistant to chemotherapy drugs. A curcumin-based compound (FLLL32), added to head and neck cancer cell lines, was able to cut the dose of the anti-cancer chemotherapy drug Cisplatin by four while still killing tumor cells equally as well as the higher dose of cisplatin without FLLL32.

Applications

Alzheimer's disease, appetite loss, arthritis, bursitis, chemotherapy, cystic fibrosis, gallbladder problems, gout, high cholesterol, hypertension, injuries, jaundice, kidney disease, liver disease, lupus, malaria, potentiate the effect of chemotherapy, avoiding and remedy of cancer, prostatitis, ulcers, urinary tract infection (UTI).
It inhibits the destruction of the joints from arthritis by inhibiting the protein NF-kB that activates an inflammatory response.
Curcumin kills cancer cells long before they can be detected; it induces cancer cell apoptosis (cell suicide).
Epidemiological studies have linked the frequent use of turmeric to lower rates of breast, prostate, lung and colon cancer.
As such is has high promise to be used as an adequate natural cancer remedy and avoiding medicine.

Dosage

Against cholesterol: 1, 5 - 2 ml. (45 - 60 drops), 3 - 4 times daily.
Cancer: 2000 - 4000 mg / powder daily.
Other applications:
Tincture: 1½ - 2 ml.
Infusion (herbal tea): 1 - 2 cups daily.
To improve bio availability of Curcumin as a tea (Tumeric extract), add black pepper or piperine.

Precaution

Side effects and / or interactions
Turmeric is "generally recognized as safe" (GRAS), as a food additive by the FDA and serious adverse effects have not been reported in humans taking high doses of Curcumin.
It is also on the Commission E (Germany’s regulatory agency for herbs) list of approved herbs.
If you take medications or undergo chemo- and / or radiotherapy for treating cancer, be cautious about possible interactions of Curcumin. Consult your oncologist and radiologist.
Patients with gallstones, bile duct obstruction, stomach ulcers and hyperacidity disorders should refrain from taking this herbal supplement.
As a precautionary measure, Curcumin should not be used during pregnancy unless under supervision of a physician.
Anticoagulants / antiplatelets: Curcumin may increase risk of bleeding.
When using non-steroidal pain relievers (Ibuproven), avoid Curcumin.

For more information on Curcumin, go to the "Curcuma xanthorrhiza plant" page.

Reference

United States Patent 5120538.
http://www.freepatentsonline.com/5120538.html
This invention relates to naturally occurring pharmaceutical compositions, more particularly, those compositions of compounds isolated from the plant genus Curcuma, which are useful as anti-inflammatory agents.

Inhibition of growth and sensiti- zation to cisplatin-mediated killing of ovarian cancer cells by polyphenolic chemopreventive agents.
Chan MM, Fong D, Soprano KJ, Holmes WF, Heverling H.
J Cell Physiol. 2003 Jan;194(1):63-70.

Curcumin (diferuloylmethane) down-regu- lates the constitutive activation of nuclear fac- tor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis.
Bharti AC, Donato N, Singh S, Aggarwal BB.
Blood. 2003 Feb;101(3):1053-62.

Anticancer potential of curcumin: preclinical and clinical studies.
Aggarwal BB, Kumar A, Bharti AC.
Anticancer Res. Jan-Feb 2003;23(1A):363-98.

Potent protective effects of sesquiterpenes and curcumin from Zedoariae Rhizoma on liver injury induced by D-galactosamine/lipopolysaccharide or tumor necrosis factor-alpha.
Morikawa T, Matsuda H, Ninomiya K, Yoshikawa M.
Medicinal foodstuffs. XXIX. Kyoto Pharmaceutical University, Japan.

The above presentation is for informational and educational purposes only.
It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage.
For many of the conditions discussed, treatment with prescribed (RX) or over - the - counter (OTC) medication is also available.
Consult your doctor, practitioner, and/or pharmacist for any health problem and before using dietary supplements or before making any changes in prescribed medications.

Buy 6 bottles save 10%; buy 12 bottles and save 15%!
(Discount is included in the sales price).

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Item	Description	Unit	Price	Quantity

Curcumin forte	tincture	1 fl. oz (29.6 cc)	US$ 15.40
Curcumin forte	tincture	6 x 1 fl. oz	US$ 83.16
Curcumin forte	tincture	12 x 1 fl. oz	US$ 157.08
Curcumin forte	tincture	2 fl. oz (59.1 cc)	US$ 28.00
Curcumin forte	tincture	6 x 2 fl. oz	US$ 151.22
Curcumin forte	tincture	12 x 2 fl. oz	US$ 285.64
Curcumin forte	tincture	1 x 32 fl. oz	US$

Curcumin xanthorriza	tincture	1 fl. oz (29.6 cc)	US$ 12.98
Curcumin xanthorriza	tincture	6 x 1 fl. oz	US$ 70.07
Curcumin xanthorriza	tincture	12 x 1 fl. oz	US$ 132.28
Curcuma xanthorriza	tincture	2 fl. oz (59.1 cc)	US$ 20.45
Curcuma xanthorriza	tincture	6 x 2 fl. oz	US$ 110.43
Curcuma xanthorriza	tincture	12 x 2 fl. oz	US$ 208.59

Curcuma xanthorriza	powder	1 lb	US$ 36.00
Curcuma xanthorriza	powder	5 lbs (34.20 /lb)	US$ 171.00
Curcuma xanthorriza	powder	10 lbs (32.40/ lb)	US$ 323.95
Curcuma xanthorriza	powder	50 lbs (30.59 /lb)	US$ 1529.60

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References:

On tumor cells in a lab dish, curcumin prevents or slows prostate and lung cancer. But dietary consumption of turmeric, researchers report, so far shows no effect on those organs and failed to inhibit tobacco - induced tumors
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Recent studies found that curcumin has a doce - dependent chemopreventive effect in rats during promotion / progression stages of colon cancer
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Tufts researchers say "a mixture of curcumin and isoflavonoids is the most potent inhibitor against the growth of human breast tumor cells". These data suggest that combinations of natural plants compounds may have preventive and therapeutic applications against the growth of breast tumors induced by environmental estrogens (Environ Health Prspect 1998 Dec; 106 (12): 807 - 12).

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Chan MM, Fong D, Soprano KJ, Holmes WF, Heverling H, Inhibition of growth and sensiti - zation to cisplatin - medicated killing of ovarian cancer cells by polyphenolic chemopreventive agaents. J Cell Physiol. 2003 Jan; 194 (1): 63 - 70.

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